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JUNE 25TH 2013 | Manchester, UK, F2G Limited, a privately-held antifungal drug discovery and development company and The University of Manchester, today announced the commencement of a 6.1 million euro EU -funded project to discover and develop novel antifungal drugs to treat serious, life-threatening fungal infections. The NOFUN project is a collaborative project under the 7th Framework Program of the European Commission which brings together five partners to accelerate the development of a number of F2G’s broad spectrum antifungal agents.

About two million people die each year because of fungal infection and resistance is rapidly emerging to the most common drugs used to treat these diseases. This project aims to develop novel agents with completely new ways of acting in order to combat the increasing tide of drug resistant fungal infections. NOFUN will use F2G’s discovery assets and the University’s fungal genomics platforms in addition to the drug development and characterisation expertise of the other partners.

Participants in the NOFUN Project are F2G Ltd (UK), The University of Manchester (UK), Pharmacelsus GmbH (Germany), OncoTargeting AB (Sweden) and Universitat i Rovira Virgili (Spain).

Dr Mike Birch of F2G and Scientific Coordinator of NOFUN added: “Competition for funding in this call was immense and the NOFUN award represents a significant validation of the project and the partners. F2G is delighted to lead the scientific program to develop much needed new antifungal agents”.

Dr Mike Bromley, NOFUN Project Coordinator from The Manchester Fungal Infection Group at The University of Manchester, said: “We are delighted that this project has been funded and it confirms The University of Manchester as a centre of excellence in fungal biology and disease. Hopefully this cash boost will help us to create new treatments to tackle serious, life-threatening fungal infections.”

About F2G Ltd:

Based in Manchester, UK, F2G Ltd is dedicated to the
discovery and development of new and clinically superior drug classes to treat
life-threatening systemic fungal infections in at-risk patient populations. This is a growing health risk for which there are currently limited treatment options and for which demand is increasing globally. Market growth is expected to increase with the emergence of new clinical indications in allergies and asthma. For more information visit www.f2g.com

MARCH 18th 2013 | Manchester, UK  F2G Limited, the UK-based antifungal drug discovery and development company, today announced the appointment of Ian Nicholson to the position of CEO and to the Board of Directors. Ian has over 25 years of international experience in management and transactions within the life sciences sector. He is currently, and will remain, an Operating Partner of London-based Advent Life Sciences LLP. Previously he spent eight years as CEO of the privately held Oncology R&D company, Chroma Therapeutics Limited. Before that he was senior vice president for business development at UK biotechnology company Celltech Group, and has worked extensively in licensing, M&A, and market development in the UK, Europe and the US. Ian holds a BSc (Hons) from University College London and an MBA from Boston University.

Dr Richard White, Executive Chairman of F2G, commented ‘We are delighted to
welcome such an experienced executive to lead the company, and I look
forward to working closely with him.’ Dr. White will revert to his former role of
Non-Executive Chairman. Ian Nicholson added ‘I am excited to join F2G at this
critical stage and lead the company in the successful development of an
important first-in-class drug to treat Aspergillosis, an area of high unmet medical need.’

About F2G Ltd:

Based in Manchester, UK, F2G Ltd is dedicated to the
discovery and development of new and clinically superior drug classes to treat
life-threatening systemic fungal infections in at-risk patient populations. This is a growing health risk for which there are currently limited treatment options and for which demand is increasing globally. Market growth is expected to increase with the emergence of new clinical indications in allergies and asthma. For more information visit www.f2g.com

Manchester, UK, February 19th 2013 – F2G Limited, the UK-based antifungal drug discovery and development company, today announced the appointment of Dr. John H. Rex to the Company’s Board as an Independent Director. Dr. Rex is a distinguished research scientist and recognized as an opinion leader in the field of infectious disease therapy and, in particular, for antifungal agents. He has a BA in Biochemistry from Rice University, an MD from Baylor College of Medicine, and is Vice President and Head of Infection, Global Medicines Development, at AstraZeneca.

Prior to joining AstraZeneca in 2003, Dr. Rex was Professor of Medicine at the University of Texas Medical School-Houston. Dr. Rex has been the Industry Representative on the US FDA Anti-Infective Drug Advisory Committee (2007-2011), is Vice-Chair of the Consensus Committee on Microbiology for the Clinical Laboratory Standards Institute (CLSI, formerly NCCLS), is a Highlights Advisor for Nature Reviews Microbiology, is a member of the Wellcome Trust Seeding Drug Discovery Committee, serves on several editorial boards, was formerly an Editor for Antimicrobial Agents and Chemotherapy, and is an Emeritus Editor for www.doctorfungus.org, a non-profit web site devoted to dissemination of information about medical mycology.

Dr. Richard White, Executive Chairman of F2G, commented, “We are delighted to have John join the board and look forward to benefiting from the breadth and depth of his knowledge and experience in the antifungal arena”.

Dr. Rex will become a key member of the Board’s Science Committee, chaired by Dr. Raj Parekh, who remarked “John’s counsel will be critical in helping F2G successfully develop its totally novel class of drugs to treat Aspergillosis – a potentially life-threatening infection usually affecting the lungs.”

Dr. Rex, who will continue his role at AstraZeneca, added, “This is an exciting time to be involved with F2G and participate in bringing a new class of antifungal agents into clinical practice. Aspergillosis remains a serious disease in an era of increasing resistance with few treatment options. In addition, I view this opportunity to work with F2G as a chance to collaborate and bring insights from the biotechnology sector into the anti-infective development work at AstraZeneca.”

About F2G Ltd:

Based in Manchester, UK, F2G Ltd is dedicated to the discovery and development of new and clinically superior drug classes to treat life-threatening systemic fungal infections in at-risk patient populations. This is a growing health risk for which there are currently limited treatment options and for which demand is increasing globally Market growth is expected to increase with the emergence of new clinical indications in allergies and asthma. For more information visit www.f2g.com

Manchester, UK, Sept 5th 2012 – F2G Limited, an antifungal drug discovery and development company, today announced the completion of a $30 million equity financing round in which two new investors (Advent Life Sciences and Novartis Bioventures) joined the existing syndicate (Sunstone Capital, Merifin Capital, K Nominees, and Astellas Venture Fund). These funds will be used to select a clinical candidate from the F3 series of advanced preclinical analogs and proceed to first in man studies. The F3 series represents a proprietary group of compounds with highly potent and selective activity against Aspergillus species and other moulds, which act via a totally novel mechanism. Aspergillus infections are a serious threat in immune-compromised patient populations and result in a high rate of mortality even with the most effective treatment currently available. Dr Richard White, chairman of F2G, commented, “We are delighted to welcome two top tier investors into F2G. We now have a first class international syndicate, including the venture arms of two major pharmaceutical companies”.

Shane Kelly, previously the CEO, is leaving the company to pursue another opportunity. Dr White will assume the expanded role of Executive Chairman and noted “We would all like to thank Shane for his tireless and steadfast management of the company over the last 10 years and for bringing us to this successful juncture. We wish him well in his new venture”

Dr Raj Parekh of Advent and Dr Anja König of Novartis Venture Funds will both be joining the Board of F2G. Raj Parekh, General Partner at Advent said, “The F2G molecules show a compelling and novel profile and have the genuine potential to be first- and best- in-class agents for the treatment of invasive aspergillosis, which remains a serious unmet medical need. We look forward to working with Richard and the team to bring these molecules to an early clinical evaluation.”

About F2G Ltd:

Based in Manchester, UK, F2G Ltd is dedicated to the discovery and development of new and clinically superior drug classes to treat life-threatening systemic fungal infections in at-risk patient populations. The antifungal market is currently estimated at over 6 billion dollars annually and is growing steadily year on year. Market growth is expected to increase with the emergence of new clinical indications in allergies and asthma. The company has impressive internal capabilities, employing a core team of scientists with a unique understanding of the antifungal arena, supported by an experienced management team. For more information visit www.f2g.com

Manchester, UK, 11 September 2010 – F2G Limited, the UK based antifungal drug discovery and development company, today announced the appointment of Dr Michael R. Hodges to the Company’s Board of Directors.

Michael R Hodges, M.D., BSc., MRCP (UK) has 20 years of biopharmaceutical development experience and has worked in both biotechnology and large pharmaceutical companies. Whilst at Pfizer Inc. Dr. Hodges was the development team leader for Vfend™, the gold standard therapy for invasive aspergillosis, as well as working on the Eraxis™ and Diflucan™ antifungal programs. In addition Dr. Hodges worked on the Zithromax™ and HIV portfolio development programs.

Prior to joining industry at Pfizer Inc. in 1990, Dr. Hodges practiced internal medicine in London, UK. 1989-90 he held an appointment through the Medical Research Council (UK), at St Thomas’ Hospital, London, HIV clinical trials unit. From 1992 to 2001 he held honoree positions with East Kent Hospitals University NHS Foundation Trust.

Shane Kelly, Chief Executive of F2G commented “It is with great pleasure that we announce that Michael Hodges has accepted our invitation to join the Board. His track record in the successful development and transition of antifungals to market will be invaluable as F2G continues to advance its portfolio of antifungal agents.”

Dr Richard White, Chairman of the Board added “We are delighted to welcome Michael to the Board. His knowledge and experience in the antifungal sector will be a considerable asset to F2G and I look forward to working with him towards the further development of F2G’s antifungal programs.”

Commenting on his appointment, Dr Michael Hodges said “I am delighted to be joining the Board of Directors, especially at such an exciting time for the company as they move their series of novel antifungal drug candidates into the clinic”.

About F2G Ltd:

Based in Manchester, UK, F2G Ltd is dedicated to the discovery and development of new and clinically superior drug classes to treat life-threatening systemic fungal infections in at-risk patient populations. The antifungal market is currently estimated at over 6 billion dollars annually and is growing steadily year on year. Market growth is expected to increase with the emergence of new clinical indications in allergies and asthma.

The company has impressive internal capabilities, employing a core team of scientists with a unique understanding of the antifungal arena, supported by an experienced management team. F2G operates a flexible business model, building value through the development of a balanced portfolio of antifungal assets across multiple validated TPPs.

For more information visit www.f2g.com

Contact:

Shane Kelly
Chief Executive Officer
F2G Ltd
Tel: (+44) 0161 785 1271
Fax: (+44) 0161 785 1273
Email: shanekelly@f2g.com

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Contact us

F2G Ltd
Lankro Way
Eccles
Manchester
United Kingdom
M30 0LX

Telephone | +44 (0)161 785 1270
Fax | +44 (0)161 785 1273
email |  contact@f2g.com


Registered in England and Wales. Company Registration No. 03578625, VAT Reg No. 712680645.